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Emerging tools such as single-cell metabolomics, spatial transcriptomics, and spatial metabolomics offer unprecedented resolution for analyzing the cellular and metabolic landscapes of the TME (316318)

The trajectory suggests exciting possibilities, but also key research gaps

Oxidative stress is a key driver of uneven pigmentation, triggering excess melanin production in localised areas

Although it is not an FDA-approved formulation, hydroxocobalamin is recommended worldwide by the World Health Organization (WHO) as a drug of choice for the treatment of vitamin B12 deficiency

Interestingly, under specific laboratory conditionstypically involving transgenic animals expressing the species-matched target proteinpathology characteristic of the originating disease can be transmitted to recipient hosts or even cultured cells (Jucker and Walker, 2018

Approximately 40% of U.S